摘要 |
The present invention relates to a method of identifying an inhibitor of a receptor tyrosine kinase that irreversibly binds to the kinase. Specifically, the method comprises using a variety of assays, either alone or in combination, to identify compounds that irreversibly bind to tyrosine kinases. More specifically, there are four assays, which are novel variations of a basic enzyme assay and identify irreversible binding inhibitors. |
申请人 |
WYETH;LOGANZO, FRANK, JR.;GREENBERGER, LEE, M.;TAN, XINGZHI;WISSNER, ALLAN |
发明人 |
LOGANZO, FRANK, JR.;GREENBERGER, LEE, M.;TAN, XINGZHI;WISSNER, ALLAN |