DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2 (NR0B2)

摘要

The invention provides a human NR0B2 which is associated with the cardiovascular diseases, metabolic diseases, inflammation, gastroenterological diseases, muscle skeleton diseases, respiratory diseases, reproduction diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, metabolic diseases, inflammation, gastroenterological diseases, muscle skeleton diseases, respiratory diseases, reproduction diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NR0B2 as well as pharmaceutical compositions comprising such compounds.