摘要 |
(E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R<SUB>1 </SUB>is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R<SUB>2 </SUB>and R<SUB>3 </SUB>are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxyl, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R<SUB>1 </SUB>may not be halogen when R<SUB>2 </SUB>and R<SUB>3 </SUB>are both halogen; R<SUB>2 </SUB>may not be 2-halogen when R<SUB>3 </SUB>is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: wherein: R<SUB>4 </SUB>is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R<SUB>6 </SUB>is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R<SUB>7 </SUB>is selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, dimethylamino (C2-C6 alkoxy) and trifluoromethyl; provided R<SUB>5 </SUB>and R<SUB>6 </SUB>may not be hydrogen in the same compound; or a pharmaceutically acceptable salt thereof. |
申请人 |
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
REDDY, E., PREMKUMAR;REDDY, M., V., RAMANA |