发明名称 SUBSTITUTED DERIVATIVES OF DIAMINO-1,3,5-TRIASINE, PHARMACEUTIC COMPOSITION, METHOD OF OBTAINING PHARMACEUTIC COMPOSITION AND METHOD OF OBTAINING SUBSTITUTED DERIVATIVES OF DIAMINO-1,3,5-TRIASINE
摘要 This invention concerns the compounds of formula <CHEM> the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R<1> and R<2> are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar<1>; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)aminocarbonyl; dihydro-2(3H)-furanone; or R<1> and R<2> taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)aminoC1-4alkylidene; R<3> is hydrogen, Ar<1>, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R<4>, R<5>, R<6>, R<7> and R<8> are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar<1> is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.
申请公布号 PL190155(B1) 申请公布日期 2005.11.30
申请号 PL19970322369 申请日期 1997.09.30
申请人 JANSSEN PHARMACEUTICA NV 发明人 KUKLA MICHAEL JOSEPH;LUDOVICI DONALD W.;JANSSEN PAUL ADRIAAN JAN;HEERES JAN;MOEREELS HENRI EMIEL LODEWIJK
分类号 A61K31/53;A61P31/12;A61P31/18;A61P37/04;C07D251/18;C07D251/22;C07D403/06;C07D405/12;C07D409/12 主分类号 A61K31/53
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