PROCESS FOR THE PREPARATION OF 4-(3'-CHLORO-4'-FLUOROANILINO) -7-METHOXY-6-(3-MORPHOLINOPROPOXY) QUINAZOLINE

摘要

Chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4-(3′-chloro-4′-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline, in particular processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one of Formula II and 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile of Formula III and their use in the manufacture of the quinazoline derivative.