发明名称 |
COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY |
摘要 |
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells. |
申请公布号 |
EP1599572(A2) |
申请公布日期 |
2005.11.30 |
申请号 |
EP20040711085 |
申请日期 |
2004.02.13 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
EPSTEIN, ALAN, L.;LI, JIALI;HU, PEISHENG |
分类号 |
A61K47/48;A61K38/19;A61K39/395;A61K47/42;A61K51/10;A61P35/00;C07K14/52;C07K14/525;C07K14/535;C07K14/55;C07K14/57;C07K16/00;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N;C12N1/00;(IPC1-7):C12N1/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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