发明名称 PHARMACEUTICAL FORMULATIONS OF ANTINEOPLASTIC AGENTS IN PARTICULAR TEMOZOLOMIDE PROCESSES OF MAKING AND USING THE SAME
摘要 In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.
申请公布号 ZA200406632(B) 申请公布日期 2005.11.30
申请号 ZA20040006632 申请日期 2004.08.19
申请人 MERCK SHARP & DOHME CORP 发明人 Sydney UGWU;Peter M IHNAT;Vinay RADHAKRISHNAN;Leonore C WITCHEY-LAKSHMANAN
分类号 A61K;C07D487/04;A61K9/19;A61K31/395;A61K31/4188;A61K31/522;A61K31/66;A61K31/704;A61K47/04;A61K47/10;A61K47/12;A61K47/18;A61K47/26;A61K47/34;A61K47/36;A61K47/38;A61K47/40;A61P35/00 主分类号 A61K
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