发明名称 |
POLYMER FOR BINDING AMINE- CONTAINING LIGANDS AND USES THEREOF |
摘要 |
<p>Reaction of a dialdehyde, particularly phthaldialdehyde (I), with R-Z where Z is a nucleophilic group (preferably SH) and R is polymerisable (e.g. allyl) gives a reactive thioacetal (V) which can react with an amine ligand L-NH2 to produce an isoindole (IV) which may be fluorescent. At some stage, generally before interaction with L-NH2, the R groups are polymerised, possibly leading to self-assembly of the polymer on a metal or SH-bearing surface. Such a coated surface is useful as a transducer in assays or as a binding medium e.g. for chromatography.</p> |
申请公布号 |
EP1173761(B1) |
申请公布日期 |
2005.11.30 |
申请号 |
EP20000927443 |
申请日期 |
2000.04.25 |
申请人 |
CRANFIELD UNIVERSITY |
发明人 |
WESTON, DAVID;TURNER, ANTHONY, PETER, FRANCIS;CULLEN, DAVID, CHARLES;PILETSKY, SERGIY, A.;PILETSKA, OLENA, VOLODIMIRIVNA;SCHEDLER, UWE |
分类号 |
G01N33/543;(IPC1-7):G01N33/543 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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