发明名称 |
PROCESS FOR THE SYNTHESIS OF 1,3,4,5-TETRAHYDRO-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID |
摘要 |
Preparation of N-substituted tetrahydro-3-benzazepine derivatives (I) by catalytic hydrogenation of the corresponding dihydro compound (VI) at 40-80[deg]C, then filtering and crystallizing the product. Preparation of N-substituted 3-benzazepine derivatives of formula (I) by catalytic hydrogention of the corresponding dihydro compound of formula (VI) at 40-80[deg]C, then filtering and crystallizing the product. R 1 and R 21-6C linear or branched alkoxy or together complete a 1,3-dioxan or 1,3-dioxolan ring Independent claims are also included for the following: (1) (I) as new compounds; and (2) method for synthesis of ivabradine or its pharmaceutically acceptable salts from (I). [Image]. |
申请公布号 |
ZA200501468(B) |
申请公布日期 |
2005.11.30 |
申请号 |
ZA20050001468 |
申请日期 |
2005.02.18 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
JEAN-MICHEL LERESTIF;JEAN-PIERRE LECOUVE;JEAN-CLAUDE SOUVIE;DANIEL BRIGOT |
分类号 |
A61K31/55;A61P9/00;A61P9/06;A61P9/10;C07B61/00;C07D223/16;C07D405/06 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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