发明名称 CYANOGUANIDINES AN INHIBITORS OF CELL PROLIFERATION
摘要 The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms,the attachment to the pyridine ring being in the 3- or 4-position, in which formula R stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C1-C4 alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C5-C14 divalent hydrocarbon radical which can be straight, branched, cyclic, saturated or unsaturated and X stands for carboxy, C1-C4 alkoxycarbonyl, di(C1-C4 alkoxy)-phosphinoyloxy, amino, C1-C4 alkoxycarbonylamino or tetrahydropyranyloxy; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.
申请公布号 PL190249(B1) 申请公布日期 2005.11.30
申请号 PL19980337059 申请日期 1998.05.15
申请人 LEO PHARMACEUTICAL PRODUCTS LTD.AS LOVENS KEMISKEFABRIK PRODUKTIONSAKTIESELSKAB 发明人 SCHOU CHARLOTTE;OTTOSEN ERIK RYTTER
分类号 C07D213/74;A61K31/44;A61P17/06;A61P35/00;A61P43/00;C07D213/75;C07D213/84;C07D405/12 主分类号 C07D213/74
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