发明名称 |
MILLING PROCESS FOR THE PRODUCTION OF FINELY MILLED MEDICINAL SUBSTANCES |
摘要 |
The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced. |
申请公布号 |
HU224615(B1) |
申请公布日期 |
2005.11.28 |
申请号 |
HU20010004478 |
申请日期 |
1999.12.01 |
申请人 |
AVENTIS PHARMA LIMITED, WEST MALLING |
发明人 |
VEMURI, N. MURTI;BROWN, ANDREW B.;AUTHELIN, JEAN-RENE;HOSEK, PATRICK |
分类号 |
A61K9/12;A61K9/00;A61K9/14;A61K31/137;A61K31/573;A61P11/06;A61P29/00;B02C19/06;B02C19/16;B02C23/06 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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