TRICYCLIC INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMERaCOES DISEASE.

摘要

The present invention relates to novel hydroxyethylamine compounds having Asp2 (beta-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated beta- amyloid levels or beta-amyloid deposits, particularly Alzheimer's disease.