发明名称 Use of amino acids for treating pain
摘要 Use of an amino acid of the general Formula I, in which one of the residues R1 and R2 denotes C1-3 alkyl, in each case unsubstituted or mono- or polysubstituted; and the other of the residues R1 and R2 denotes branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted C3-10 alkyl; or aryl/heteroaryl, in each case unsubstituted or monosubstituted; or unsubstituted or monosubstituted C3-8 cycloalkyl; or R1 and R2 together form a ring and denote substituted or unsubstituted (CH2)5, so that a substituted or unsubstituted cyclohexyl is obtained, optionally in the form of a racemate, a pure stereoisomer, or in the form of a mixture of the stereoisomers in any mixing ratio; in the form given or in the form of an acid or a base or in the form of a salt, or in the form of a solvate, to manufacture a medicament for treating pain, epilepsy and/or migraines or to manufacture a medicament for treating hyperalgesia or allodynia, or inflammatory or postoperative pain or to manufacture a medicament for treating hot flushes, postmenopausal complaints, amyotrophic lateral sclerosis (ALS), reflex sympathetic dystrophy (RSD), spastic paralysis, restless leg syndrome, acquired nystagmus; psychiatric or neuropathological disorders; painful diabetic neuropathy, symptoms and pain due to multipte sclerosis or Parkinson's disease, neurodegenerative diseases; gastric intestinal injury; erythromelalgic or post-poliomyelitic pain, trigeminal or post-therapeutic neuralgia; or as an anticonvulsive, analgesic or anxiolytic.
申请公布号 NZ525250(A) 申请公布日期 2005.11.25
申请号 NZ20010525250 申请日期 2001.09.28
申请人 GRUNENTHAL GMBH 发明人 CHIZH, BORIS;PUTZ, CLAUDIA KATHARINA;HAURAND, MICHAEL
分类号 C07D295/08;A61K31/137;A61K31/381;A61K31/495;A61K31/496;A61P21/02;A61P21/04;A61P25/00;A61P25/02;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P29/00;C07C213/00;C07C215/24;C07C215/28;C07C215/30;C07C215/42;C07C215/44;C07C217/54;C07C217/64;C07C217/74;C07D295/096;C07D307/52;C07D333/20;(IPC1-7):C07C229/28;C07C229/08;A61K31/195 主分类号 C07D295/08
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