Sustained release pharmaceutical composition

摘要

A sustained release apparatus including a plurality of sustained release mini-implants or pellets; each mini-implant including: a sustained release support material; and a pharmaceutically active composition carried in or on the sustained release support material; the pharmaceutically active composition including: at least one pharmaceutically active component; and a carrier therefore; each implant being of insufficient size and/or payload individually to provide a predetermined desired threshold blood level of pharmaceutical active for treatment of a selected indication; the size(s) of the mini-implants or pellets providing zero order release of pharmaceutical active; the sustained release apparatus providing, in use, zero order release of pharmaceutically active at, or above, the desired threshold level of pharmaceutical active treatment of a selected indication, is disclosed. A sustained release kit is also disclosed. The described sustained release mini-implants or pellets are useful in the manufacture of a sustained release delivery apparatus for the therapeutic or prophylactic treatment of a disease condition in an animal. A method for the therapeutic or prophylactic treatment of a disease condition in an animal (not including a human) requiring such treatment, which method includes administering to the animal a sustained release delivery apparatus as described above is also disclosed.