Controlled release sulfonylurea formulation

摘要

Disclosed herein is a controlled release oral dosage form, which comprises: (a) a core comprising: (i) glipizide a sulfonylurea or a pharmaceutically acceptable salt thereof; (ii) a pharmaceutically acceptable polymer; and (b) a membrane surrounding the core which is permeable to the glipizide or pharmaceutically acceptable salt thereof (said membrane including a methacrylic acid copolymer and having at least one passageway) and gastrointestinal fluid, wherein the dosage form being suitable for providing once-a-day oral administration of the glipizide or pharmaceutically acceptable salt thereof, and wherein the dosage form provides a mean time to maximum plasma concentration (Tmax) of said glipizide or pharmaceutically acceptable salt thereof at from 4 to 16 hours after oral administration to human patients.