<p>The present invention provides a spectroscopic system and in particular a fiber optic probe for in vivo detection of vulnerable atherosclerotic plaque inside the cardiovascular system of a patient. Detection of vulnerable plaque is based on a location dependent measurement of concentration levels of cardiac marker molecules flowing in the blood stream. Concentration level determination is preferably based on surface-enhanced Raman spectroscopic techniques providing sufficient sensitivity for determination of these concentration levels. Acquisition of spectroscopic data during moving of the fiber optic probe through the cardiovascular system with controlled velocity allows to precisely locate vulnerable plaque in the cardiovascular system.</p>
申请公布号
WO2005111558(A1)
申请公布日期
2005.11.24
申请号
WO2005IB51498
申请日期
2005.05.09
申请人
KONINKLIJKE PHILIPS ELECTRONICS N. V.;LUCASSEN, GERALD;GIJSBERS, GEERT;VAN BEEK, MICHAEL CORNELIS;NEERKEN, SIEGLINDE
发明人
LUCASSEN, GERALD;GIJSBERS, GEERT;VAN BEEK, MICHAEL CORNELIS;NEERKEN, SIEGLINDE