发明名称 |
Method of forming microparticles that include a bisphosphonate and a polymer |
摘要 |
Microparticles that include a bisphosphonate and a polymer are produced by a method that includes forming a water-in-oil emulsion by mixing an aqueous solution of the bisphosphonate with a combination of a biocompatible polymer and a polymer solvent. At least one aqueous liquid can be mixed with the water-in-oil emulsion to form a water-in-oil-in-water emulsion and to extract the polymer solvent from the polymer, thereby forming the microparticles. Methods of treating a patient in need of therapy include administering the microparticles described to the patient. In one embodiment, the microparticles are formulated for the sustained release of the bisphosphonate.
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申请公布号 |
US2005260272(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050122796 |
申请日期 |
2005.05.05 |
申请人 |
ALKERMES CONTROLLED THERAPEUTICS, INC. |
发明人 |
FIGUEIREDO MARIA C.;KUMAR RAJESH;MALONEY MAURA J.;PRINN KRISTIN;SCHER DAVID S.;TROIANO GREGORY C.;YEOH THEAN Y.;ZALE STEPHEN E. |
分类号 |
A61K9/14;A61K9/16;A61K9/19;A61K9/50;A61K31/66;A61K31/675;B01J13/02;B01J13/04;C08L23/08;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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