| 摘要 |
The present invention provides porcine Forssman synthetase (FSM snythase) (Globoside .alpha.-N-acetylgalactosaminyltransferase) protein, cDNA, and genomic DNA sequence. Furthermore, the present invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional FSM synthetase. Such animals, tissues, organs and cells can be used in research and in medical therapy, including in xenotransplantation. In addition, metho ds are provided to prepare organs, tissues, and cells lacking the porcine FSM synthetase gene for use in xenotransplantation.
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