Compounds for intracellular delivery of therapeutic moieties to nerve cells

摘要

A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: <?in-line-formulae description="In-line Formulae" end="lead"?>B-L-TM <?in-line-formulae description="In-line Formulae" end="tail"?> where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.