发明名称 |
Non-natural ribonuclease conjugates as cytotoxic agents |
摘要 |
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells. |
申请公布号 |
US2005261232(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050105041 |
申请日期 |
2005.04.13 |
申请人 |
QUINTESSENCE BIOSCIENCES, INC. |
发明人 |
STRONG LAURA E.;LELAND PETER A.;BURKE THOMAS |
分类号 |
A61K39/395;A61K47/48;A61K48/00;(IPC1-7):A61K48/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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