7-T-BUTOXYIMINOMETHYLCAMPTOTHECIN CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS

摘要

Compounds of Formula (I) are described; in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.