2' ,5' -Oligoadenylate analogs

摘要

A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R¹ represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R², R³, R⁴, R⁵ and R⁶ represent an unprotected hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R⁷ represents an oxygen atom, or a -O(CH₂CH₂O)q-group, wherein q is 2 to 6; R⁸ represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted, or a 5'-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5'-phosphoric acid group; E¹, E², E³ and E⁴ represent a naturally occurring or modified nucleic acid unit, or a pharmacologically acceptable salt thereof.