发明名称 |
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
摘要 |
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
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申请公布号 |
US2005261245(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050521075 |
申请日期 |
2005.01.12 |
申请人 |
BERTHELETTE CARL;LACHANCE NICHOLAS;LI LIANHAI;STURINO CLAUDIO;WANG ZHAOYIN;YOUNG ROBERT N;DUFRESNE CLAUDE |
发明人 |
BERTHELETTE CARL;LACHANCE NICHOLAS;LI LIANHAI;STURINO CLAUDIO;WANG ZHAOYIN;YOUNG ROBERT N.;DUFRESNE CLAUDE |
分类号 |
A61K31/422;A61K31/427;A61K31/496;A61K31/506;A61K31/5377;A61K31/541;A61K31/675;A61P29/00;C07C317/46;(IPC1-7):A61K31/675;A61K31/537 |
主分类号 |
A61K31/422 |
代理机构 |
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