发明名称 |
LEPTIN PEPTIDE ANTAGONISTS |
摘要 |
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence. |
申请公布号 |
WO2005110461(A2) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005US15198 |
申请日期 |
2005.05.03 |
申请人 |
BOSTON BIOMEDICAL RESEARCH INSTITUTE |
发明人 |
GONZALEZ, RUBEN, RENE;LEAVIS, PAUL, C. |
分类号 |
A61K38/17;A61K38/22;C07K14/575;G01N33/50;G01N33/74 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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