| 摘要 |
A pyrrolobenzodiazepine dimer compound of Formula (I): or pharmaceutically acceptable salt or solvate thereof is useful as a therapeutic agent for the treatment of leukaemias, especially B-cell leukaemias, that exhibit resistance to other chemotherapeutic drugs, wherein: the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R<2> and R<3> are independently selected from -H, =O, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R and COR; R<6>, R<7> and R<9> are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo; where R and R' are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R<10> is a carbamate-based nitrogen protecting group and R<15> is either O-R<11>, wherein R<11> is an oxygen protecting group, or OH, or R<10> and R<15> together form a double bond between N10 and C11; R" is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings, and each X is independently selected from O, S, or NH; R<2'>, R<3'>, R<6'>, R<7'>, R<9'>, R<10'> and R<15'> are all independently selected from the same lists as previously defined for R<2>, R<3>, R<6>, R<7>, R<9>, R<10> and R<15> respectively. |
