发明名称 |
MODIFIED COAGULATION FACTORS WITH ENHANCED STABILITY AND THEIR DERIVATIVES |
摘要 |
<p>The present invention relates to modified nucleic acid sequences coding for coagulation Factors, in particular human FV and human Factor VIII and their derivatives with improved stability, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.</p> |
申请公布号 |
WO2005111074(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005EP05291 |
申请日期 |
2005.05.13 |
申请人 |
ZLB BEHRING GMBH;WEIMER, THOMAS;SCHULTE, STEFAN;HOFMANN, KAY;HAUSER, HANS-PETER |
发明人 |
WEIMER, THOMAS;SCHULTE, STEFAN;HOFMANN, KAY;HAUSER, HANS-PETER |
分类号 |
C07K14/745;C07K14/755;C07K14/81;C12N9/02;C12N15/11;C12P21/02;(IPC1-7):C07K14/745;C12N15/12 |
主分类号 |
C07K14/745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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