发明名称 |
Gene regulation with aptamer and modulator complexes for gene therapy |
摘要 |
Provided is an improved method for controlling gene expression in vivo through the use of a gene switch comprising one or more aptamer sequences operably linked to or incorporated into the untranslated regions (UTRs) of a transgene or nucleotide sequence of interest. Also provided are expression vectors having aptamer sequences located within the 3' UTR, the 5' UTR and between the genes of a multicistronic mRNA, as well as methods of using the expression vectors for controlling or regulating gene expression.
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申请公布号 |
US2005260164(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050102428 |
申请日期 |
2005.04.08 |
申请人 |
JOLLY DOUG;ROHLL JONATHAN;BUEHLER BERND;MITROPHANOUS KYRI;RADCLIFFE PIPPA |
发明人 |
JOLLY DOUG;ROHLL JONATHAN;BUEHLER BERND;MITROPHANOUS KYRI;RADCLIFFE PIPPA |
分类号 |
A61K48/00;C12N15/63;C12N15/67;C12N15/86;C12N15/867;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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