NON-TOXIC BIODEGRADABLE POLYURETHANES WHICH ARE INTENDED FOR THE CONTROLLED RELEASE OF PHARMACEUTICALS AND FOR TISSUE ENGINEERING

摘要

The invention relates to a biodegradable polyurethane material having adjustable hydrophilic/hydrophobic properties and non-toxic degradation products, the main chain thereof containing at least one amino acid group, thereby rendering same recognisable by biological agents. The polymers are synthesised form a long-chain monomer, such as a polyol formed by a copolymer comprising units or segments with different hydrophilic/hydrophobic properties, a di- or polyisocyanate and a chain extender, such that: the degradation products of said three basic components do not produce toxic products, and the structure of the main chain contains at least one amino acid group. The principal applications of the invention are based on the use thereof as a material for the production of products that are intended for the pharmaceutical and biotechnological industries. More specifically, the invention is intended primarily for the transport and the controlled release of pharmaceuticals and for tissue engineering.