发明名称 |
METHODS AND COMPOSITIONS FOR DETECTING NUCLEIC ACIDS USING SCANNING PROBE MICROSCOPY AND NANOCODES |
摘要 |
A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of an isolated labeled oligonucleotides that binds to the nucleic acid is then detected using SPM. Nanocodes of the present invention in certain aspects include detectable features beyond the arrangement of tags that encode information about the barcoded object, which assist in detecting the tags that encode information about the barcoded object. The detectable features include structures of a nanocode or associated with a nanocode, referred to herein as detectable feature tags, for error checking/error-correction, encryption, and data reduction/compression. |
申请公布号 |
WO2005066368(A3) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2004US43632 |
申请日期 |
2004.12.28 |
申请人 |
INTEL CORPORATION;BERLIN, ANDREW;YAMAKAWA, MINEO |
发明人 |
BERLIN, ANDREW;YAMAKAWA, MINEO |
分类号 |
C12Q1/68;G01Q60/10;G01Q60/50 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|