发明名称 |
Cytomegalovirus disintegrin-like peptides |
摘要 |
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
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申请公布号 |
US2005260199(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050127601 |
申请日期 |
2005.05.12 |
申请人 |
COMPTON TERESA;FEIRE ADAM L |
发明人 |
COMPTON TERESA;FEIRE ADAM L. |
分类号 |
A61K38/17;A61K39/245;A61K39/395;C07K14/045;C07K14/705;C07K16/08;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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