METHODS OF TREATING WOUNDS WITH GONYAUTOXINS

摘要

Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for treating wounds, anal fissure, achalasia, disorders of the upper and lower esophageal sphincter, gastroparesis, hypertrophic pyloric stenosis, hemorrhoids, proctalgia fugax, irritable bowel syndrome, muscular spasms, vasospastic disorders, disorders involving uterine, or bladder spasm, sphincter of Oddi dysfunction, and short-segment Hirschprung's are provided. Also provided are methods of treating wounds and muscle disorders by administering the composition of the invention to a muscle or in the vicinity of a muscle either topically or by injection.