发明名称 |
AN IMPROVED PROCESS FOR THE PREPARATION OF TERBINAFINE HYDROCHLORIDE |
摘要 |
<p>The present invention relates to an improved process for preparation of terbinafine hydrochloride ,which is (E) - N- Methyl -N-(1-Naphtylmethyl)-6,6-dimethylhept-2-ene-4-ynyl-1-amine has the formula (I), which comprises reacting t-butylacetylene with ethylmagnesium bromide in THF (ii) adding acrolein at a temperature in the range of 0-10o C to get , 6,6-dimethyl-hept-1-ene-4-yne-3-ol, (iii) reacting it with a mixture of phosphorous oxychloride and hydrochloric acid in methanol (iv) extracting the reaction mass with aliphatic/aromatic solvent & removing the solvent (v) reacting the residue with N-(1-naphtylmethyl)methyl amine in the presence of a base to give Terbinafine (vi) adding hydrochloric acid and extracting the Terbinafine Hcl formed with a chlorinated solvent and (vii) recovering the chlorinated solvent under vacuum and adding ethylacetate to separate Terninafine hydrochloride which is filtered and dried.</p> |
申请公布号 |
WO2005110968(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005IN00157 |
申请日期 |
2005.05.13 |
申请人 |
HYDEX CHEMICALS PVT LTD.;GUPTA, RAJENDER, PRASHAD;SEKHAR REDDY, KAKU, VIJAY |
发明人 |
GUPTA, RAJENDER, PRASHAD;SEKHAR REDDY, KAKU, VIJAY |
分类号 |
C07C209/08;C07C211/30;(IPC1-7):C07C209/08 |
主分类号 |
C07C209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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