发明名称 |
Methods and compositions for identifying disease genes using nonsense-mediated decay inhibition |
摘要 |
The invention provides compositions and methods for diagnostic and therapeutic applications of gene identification by nonsense-mediated decay inhibition (GINI). The approach allows the rapid identification of the genes and genetic lesions responsible for monogenic as well as polygenic human genetic disorders. In addition, the approach supports diagnostic typing and therapeutic selection for human cancers and other disorders arising as a result of gene mutations. |
申请公布号 |
AU2002305174(A8) |
申请公布日期 |
2005.11.17 |
申请号 |
AU20020305174 |
申请日期 |
2002.04.12 |
申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
HARRY C. DIETZ;JOSHUA MENDELL;ERICK NOENSIE |
分类号 |
C12N15/10;C12Q1/68;G06F19/20;(IPC1-7):A23J1/00;C12P21/06;C07K1/00;A61K38/16;C12N15/63;C12N15/31;C12N1/15 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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