| 摘要 |
PROBLEM TO BE SOLVED: To obtain an ideal medicine for chemoprophylaxis of colon cancer, a medicine which is one with the following profile (1) colon specific, (2) limited absorption (absorption of the parent substance and metabolites should be minimal), (3) lack in systemic activity (once absorbed, metabolic inactivation should convert the medicine to an inactive form, thereby limiting systemic effects on the renal and GI (gastrointestinal) systems), (4) antioxidant properties (colon specific antioxidant activity would further serve to lower carcinogen burdens) and (5) NSAID (nonsteroidal anti inflammatory drugs)-like anti-inflammatory mechanism (the active metabolite should inhibit inflammation-induced eicosanoid pathways, however, eicosanoid inhibition without compromise to basal maintenance pathways would be preferred). SOLUTION: A pharmaceutical composition comprising a 2-hydroxy-5-phenylazobenzoic acid derivative represented by the formula is used for chemoprophylaxis of colon cancer. COPYRIGHT: (C)2006,JPO&NCIPI
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