发明名称 |
METHODS FOR IDENTIFYING COMPOUNDS FOR TREATING DIABETES MELLITUS |
摘要 |
<p>The invention is directed to methods for identifying candidate beta cell-sensitizing compounds comprising providing a pancreatic beta islet cell population derived from a diabetic subject, contacting the beta islet cell population with one or more somatostatin receptor 5-binding compounds, and identifying those somatostatin receptor 5-binding compounds that promote insulin secretion from the pancreatic beta islet cell population at a higher rate than from a control cell population. The invention is further directed to methods for treating type II diabetes comprising administering a beta cell-sensitizing compound identified by the first method of the invention to a diabetic patient in need of treatment.</p> |
申请公布号 |
WO2005108982(A1) |
申请公布日期 |
2005.11.17 |
申请号 |
WO2005EP04995 |
申请日期 |
2005.05.09 |
申请人 |
BIOSTRATUM AB;EFENDIC, SUAD |
发明人 |
EFENDIC, SUAD |
分类号 |
C12N5/08;C12Q1/68;G01N33/50;(IPC1-7):G01N33/50;A61P5/48 |
主分类号 |
C12N5/08 |
代理机构 |
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代理人 |
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地址 |
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