发明名称 |
MEDICAL DEVICE WITH COATING FOR CAPTURING GENETICALLY-ALTERED CELLS AND METHODS OF USING SAME |
摘要 |
Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressi ng a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal sourc e such as activator molecules for stimulating the modified cells to express an d secrete the desired marker and therapeutic gene products. |
申请公布号 |
CA2563329(A1) |
申请公布日期 |
2005.11.17 |
申请号 |
CA20052563329 |
申请日期 |
2005.04.29 |
申请人 |
ORBUS MEDICAL TECHNOLOGIES, INC. |
发明人 |
KUTRYK, MICHAEL JOHN BRADLEY;ROWLAND, STEPHEN M.;COTTONE, ROBERT J., JR. |
分类号 |
A61K48/00;A61K35/12;A61K47/48;A61L27/30;A61L27/34;A61L27/38;A61L27/54;A61L29/08;A61L29/10;A61L29/16;A61L31/08;A61L31/10;A61L31/16;C12N5/071;C12N5/074;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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