发明名称 |
Condensed pyridines and pyrimidines with tie2 (tek) activity |
摘要 |
A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR<SUP>5</SUP>; Z is selected from N and CR<SUP>6</SUP>; Q<SUP>1 </SUP>is selected from optionally substituted aryl and heteroaryl, and the substituents R<SUP>1 </SUP>to R<SUP>6 </SUP>are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.
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申请公布号 |
US2005256140(A1) |
申请公布日期 |
2005.11.17 |
申请号 |
US20050523401 |
申请日期 |
2005.02.03 |
申请人 |
LUKE RICHARD WILLIAM A;JONES CLIFFORD D |
发明人 |
LUKE RICHARD WILLIAM A.;JONES CLIFFORD D. |
分类号 |
A61K31/519;A61K31/52;A61K31/5377;A61K31/55;A61P3/10;A61P9/00;A61P9/10;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07D473/34;C07D487/04;C07D491/04;C07D491/048;C07D495/04;C07D498/04;C07D513/04;(IPC1-7):A61K31/519;C07D498/02;C07D491/02 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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