Method for discrimination of metaplasias from neoplastic or preneoplastic lesions

摘要

The present invention relates to a method for discrimination of p16^INK4a overexpressing metaplasias from neoplastic or preneoplastic p16^INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16^INK4a based detection of anogenital lesions in cytological testing procedures.