发明名称 PROCESS FOR PREPARING ONDANSETRON HYDROCHLORIDE DIHYDRATE HAVING A DEFINED PARTICLE SIZE
摘要 The invention provides a process for preparing ondansetron hydrochloride dihydrate particles in which at least about 70% of the particles have a particle size of less than 250 µm, comprising the steps of: (a) preparing a solution comprising ondansetron hydrochloride and water; and (b) adding the solution into a precipitation medium which comprises a water-miscible nonsolvent for ondansetron hydrochloride, while maintaining the resulting mixture at a temperature of about 40°C or less.
申请公布号 WO2005108392(A2) 申请公布日期 2005.11.17
申请号 WO2005IL00473 申请日期 2005.05.05
申请人 TARO PHARMACEUTICAL INDUSTRIES LTD.;GUTMAN, DANIELLA;CYJON, ROSA 发明人 GUTMAN, DANIELLA;CYJON, ROSA
分类号 A61K31/4178;C07D403/02;C07D403/06 主分类号 A61K31/4178
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