发明名称 |
PROCESS FOR PREPARING ONDANSETRON HYDROCHLORIDE DIHYDRATE HAVING A DEFINED PARTICLE SIZE |
摘要 |
The invention provides a process for preparing ondansetron hydrochloride dihydrate particles in which at least about 70% of the particles have a particle size of less than 250 µm, comprising the steps of: (a) preparing a solution comprising ondansetron hydrochloride and water; and (b) adding the solution into a precipitation medium which comprises a water-miscible nonsolvent for ondansetron hydrochloride, while maintaining the resulting mixture at a temperature of about 40°C or less. |
申请公布号 |
WO2005108392(A2) |
申请公布日期 |
2005.11.17 |
申请号 |
WO2005IL00473 |
申请日期 |
2005.05.05 |
申请人 |
TARO PHARMACEUTICAL INDUSTRIES LTD.;GUTMAN, DANIELLA;CYJON, ROSA |
发明人 |
GUTMAN, DANIELLA;CYJON, ROSA |
分类号 |
A61K31/4178;C07D403/02;C07D403/06 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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