ADAMANTYL PYRROLIDIN-2-ONE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS

摘要

The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl-, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl-; R<1> and R<2> each independently represent hydrogen, halo, cyano, hydroxy, Cl-4alkyl optionally substituted with halo, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar<1> and halo ; R<3 >represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R<4> represents hydrogen, halo, Cl-4alkyl, hydroxy, cyano or C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R<5> represents hydrogen, C1-4alkyl or Ar<2>-C1-4alkyl-; R<6> represents hydrogen, hydroxy, halo, C1-4alkyl or C1-4alkyoxy-; R<7> represents hydrogen or R<7> and R<5> taken together with the carbon atom to which they are attached from a -C2-alkyl- linker; Ar<1> and Ar<2> each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl.