发明名称 |
NGAL FOR REDUCTION AND AMELIORATION OF ISCHEMIC AND NEPHROTOXIC INJURIES |
摘要 |
Use of neutrophil gelatinase-associated lipocalin (NGAL) as a therapeutic and in a method of treating, reducing, or ameliorating an injury selected from an ischemic injury, an ischemic-reperfusion injury, and a toxin-induced injury, to an organ in a patient. The invention includes administering to the patient NGAL in an amount effective to treat, reduce or ameliorate ischemic, ischemic-reperfusion, or toxin-induced injury to the organ, such as the kidney. A siderophore can be co-administered with the NGAL. The invention also relates to administering a sideophore to enhance a response to secretion of NGAL following an ischemic or toxin-induced injury to an organ in a patient. |
申请公布号 |
WO2005107793(A2) |
申请公布日期 |
2005.11.17 |
申请号 |
WO2005US15799 |
申请日期 |
2005.05.06 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY;CHILDREN'S HOSPITAL MEDICAL CENTER;BARASCH, JONATHAN, M.;DEVARAJAN, PRASAD;MORI, KIYOSHI |
发明人 |
BARASCH, JONATHAN, M.;DEVARAJAN, PRASAD;MORI, KIYOSHI |
分类号 |
A01N1/00;A01N1/02;A61K38/17;A61K38/43;A61K39/02 |
主分类号 |
A01N1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|