发明名称 |
PHARMACEUTICAL COMPOSITIONS |
摘要 |
<p>The present invention provides bipyrimidinyl diphosphine compounds of the formula, formula (I) wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R' and R" are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible a in high enantiomeric purity according to the methods disclosed herein.</p> |
申请公布号 |
WO2005108377(A1) |
申请公布日期 |
2005.11.17 |
申请号 |
WO2005CN00654 |
申请日期 |
2005.05.11 |
申请人 |
THE HONG KONG POLYTECHNIC UNIVERSITY;CHAN, SUN-CHI, ALBERT;CHEN, GANG;GUO, RONGWEI;WU, JING |
发明人 |
CHAN, SUN-CHI, ALBERT;CHEN, GANG;GUO, RONGWEI;WU, JING |
分类号 |
C07D239/545;C07F9/02;C07F9/28;C07F9/50;C07F9/6512;C07F15/00;(IPC1-7):C07D239/545 |
主分类号 |
C07D239/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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