摘要 |
A process for the preparation of citalopram and the pharmaceutically acceptable salts therof is disclosed by reacting 5-cyanophthalide with a 4-fluorophenyl magnesium halide, reducing the 3-hydroxymethyl-4-(4- fluorobenzoyl)benzonitrile with an agent reducing ketones to alcohols, submitting the thus-obtained 3-hydroxymethyl-4- [(4-fluorophenyl) hydroxymethyl) benzonitrile to a cyclization reaction to give 1-(4- fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile without 1,1-bis(4- fluorophenyl)-1,3-dihydro-5- isobenzofurancarbonitrile and treating 1,1- bis(4 fluorophenyl)-1,3-dihydro-5- isobenzofurancarbonitrile with a 3- (dimetylamino)propyl halide in the presence of a base.
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