MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS CONTAINING PIPERIDINE DERIVATIVES AS THE ACTIVE INGREDIENT

摘要

The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula ÄIÜ: <CHEM> Äwherein R<1> is hydrogen, hydroxyl, lower alkyl, or the like; R<2>, R<3a>, R<3b>, R<4a>, R<4b>, R<5a>, R<5b> and R<6> each stands for hydrogen, halogen, or the like; W<1> and W<2> each independently stands for -O-, -CH2-, or the like; Y<1>, Y<2>, Y<3> and Y<4> stand for -CH-, -CF-, -N-, or the like; Z stands for lower alkyl, an aliphatic heterocyclic group, or the like; Ar is a mono- or bi-cyclic aliphatic heterocycle or an aromatic heterocycle; and n is an integer of 1 to 8Ü. The compounds act as antagonist against melanin-concentrating hormone receptor and are useful as drugs for central diseases, circulatory diseases, or metabolic diseases.