发明名称 |
HOMOLOGOUS 28-KILODALTON IMMUNODOMINANT PROTEIN GENES OF EHRLICHIA CANIS AND USES THEREOF |
摘要 |
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5; -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis. |
申请公布号 |
EP1317474(A4) |
申请公布日期 |
2005.11.16 |
申请号 |
EP20010970986 |
申请日期 |
2001.09.12 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
WALKER, DAVID, H.;YU, XUE-JIE;MCBRIDE, JERE, W. |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61P31/00;C07K14/195;C07K14/29;C07K16/12;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/117;C12P21/02;(IPC1-7):C07K5/00;C12N15/63;C07H21/04;C07H21/02;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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