| 摘要 |
<p>The present invention relates to new attenuated mutant Newcastle disease virus strains. In particular, it relates to an attenuated mutant Newcastle disease virus strain suitable for in ovo vaccination of avian species comprising a mutation in the gene sequences encoding the HN and/or F glycoproteins of said virus resulting in an altered expression of said glycoproteins. Furthermore, the invention relates to a vaccine composition comprising said attenuated mutant Newcastle disease La Sota virus strain, and to the use of said attenuated mutant Newcastle disease La Sota virus strain for the preparation of a vaccine for in ovo vaccination of avian species against Newcastle disease. Finally, the present invention also concerns a method for producing a vaccine for in ovo vaccination of avian species, said vaccine comprising attenuated mutant avian virus strains, which are selected using virus specific antibodies.</p> |
