发明名称 |
Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis |
摘要 |
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of the antibody with PF4 or heparin alone. The monoclonal antibody of the invention also binds specifically with PF4 in a complex with other glycosaminoglycans besides heparin, and also activates platelets. The monoclonal antibody of the invention is useful in methods for diagnosing and treating HIT/HITT in a mammal. A humanized version of the monoclonal antibody of the invention is also included, along with a process for humanizing the monoclonal antibody of the invention.
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申请公布号 |
US6964854(B1) |
申请公布日期 |
2005.11.15 |
申请号 |
US20000615872 |
申请日期 |
2000.07.13 |
申请人 |
SCIENCE & TECHNOLOGY CORPORATION |
发明人 |
AREPALLY GOWTHAMI M.;KISIEL WALTER;KAMEI KEIKO;KAMEI SHINTARO |
分类号 |
C07K16/18;C07K16/24;C12N5/20;C12P21/08;G01N33/564;G01N33/577;G01N33/86;(IPC1-7):C07K16/18 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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