发明名称 |
PROCESSES FOR PRODUCING 1-BENZYL-4-[(5,6-DIMETHOXY-1INDANON)-2-YL]METHYLPIPERIDINE AND HYDROCHLORIDE THEREOF |
摘要 |
<p>Processes for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine (donepezil), which is useful as an intermediate for medicines, and for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (donepezil hydrochloride), which is useful as a medicine. The process for donepezil hydrochloride production comprises catalytically hydrogenating the compound represented by the structural formula (III) [1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-ylidene]methylpiperidine] with a Raney nickel catalyst under mild conditions and subsequently treating it with hydrochloric acid. Thus, impurities are further diminished. The operations are simple and the process is suitable for industrial production.</p> |
申请公布号 |
WO2005105742(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
WO2005JP08028 |
申请日期 |
2005.04.27 |
申请人 |
EISAI CO., LTD.;IMAI, AKIO;NISHIMURA, HIROSHI |
发明人 |
IMAI, AKIO;NISHIMURA, HIROSHI |
分类号 |
B01J25/02;C07D211/32;(IPC1-7):C07D211/32 |
主分类号 |
B01J25/02 |
代理机构 |
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