| 摘要 |
PROBLEM TO BE SOLVED: To provide a method which simply produces an indole compound. SOLUTION: The method for manufacturing an indole compound represented by formula (3) (wherein R<SP>1</SP>, R<SP>2</SP>, and R<SP>3</SP>are each independently an alkyl group, an alkoxy group or the like; and R<SP>4</SP>is hydrogen, an alkyl group, an alkoxy group or the like) comprises reacting a (pyrimidin-2-yl)-2-propanone compound represented by formula (1) (wherein R<SP>1</SP>, R<SP>2</SP>, and R<SP>3</SP>are the same as defined above) with a hydrazine compound represented by formula (2) (wherein R<SP>4</SP>is the same as defined above) at≥120°C. This manufacturing method can produce the indole compound from the easily available raw materials by simple operations, facilitates waste disposal and is environmentally friendly due to no creation of einvironmentally harmful waste, and has high industrial usefulness. COPYRIGHT: (C)2006,JPO&NCIPI
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