Polycationic antimicrobial therapeutic

摘要

Methods of treatment for medical indications having a microbial etiology are provided using polybiguanides, particularly water insoluble and complexed with a water insoluble antimicrobial metal material. The compositions are contacted with mucosal or dermal tissue susceptible to infection or infected in an amount sufficient to inhibit proliferation and with a spaced-apart regimen due to the persistence of the composition.